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KMID : 1161420210240080833
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Journal of Medicinal Food
2021 Volume.24 No. 8 p.833 ~ p.840
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Maternal Sweeteners Intake During Gestation and Lactation Affects Learning and Memory in Rat Female Offspring
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Romero-Delgado Bianca
Cardenas-Tueme Marcela
de Jesus Herrera-de la Rosa Jose
Camacho-Morales Alberto
Castro Heriberto
de la Garza Ana Laura
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Abstract
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Maternal high-sweetener diet, such as sucrose, has been associated with an increased risk of metabolic and cognitive-related diseases in the offspring. This study was performed to determine the effect of maternal sweetener intake during gestation and lactation on learning and memory in adult female offspring rats. Twenty-eight female pups from dams fed standard diet (Control-C, n?=?10), high-sucrose diet (HS-C, n?=?6), and high-honey diet (Ho-C, n?=?12) were fed standard diet after weaning and body weight and food intake were recorded once a week for 19 weeks. Learning and memory tests were conducted at week 14 (Y-maze) and 18 (Barnes maze). We found that birth weight of Control-C group was greater than the Ho-C (P?
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KEYWORD
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Barnes maze, fetal programming, honey, memory, spatial learning, sucrose, Y-maze
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